Peripheral giant cell granuloma pubmed central pmc. Central giant cell is a benign lesion that predominantly involves the bone of the mandible and maxilla with a wide variation of its behavior. Central giant cell granuloma cgcg is a benign intraosseous lesion. The peripheral giant cell granuloma pgcg is a nonneoplastic lesion commonly caused by local irritation. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology. Ua shah, ak shah,s kumar giant cell reparative granuloma of the jaw. Central giant cell granuloma of the mandibular condyle. The lesions grew slowly and usually presented clinically as painless swellings. However, a giant cell tumour can be distinguished based on the fact that it occurs commonly between the ages of 25 and 40 years, usually involving the long bones and is more aggressive in nature, with frequent recurrence after curettage. Pdf central giant cell granuloma cgcg is a benign intraosseous lesion of unknown etiology, and occurs in jaws. The most common treatment is curettage,which has a high recurrence rate, particularly in more.
Although its cause and behavior are still matters for discussion, its early diagnosis and treatment are a priority. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad. Prathibha prasad department of oral and maxillofacial pathology. Central giant cell granuloma a case report balaji p. Nagargoje department of oral and maxillofacial surgery midsr dental college latur, maharashtra, india corresponding author a b s t r a c t. Treatment of central giant cell lesions using bisphosphonates. Seven cgcgs were treated with intralesional injection of corticosteroids. This report describes a 46yearold caucasian male who presented with a pgcg associated with a dental implant. Extremely aggressive behavior of central giant cell granuloma. Central giant cell granuloma cgcg is an intraosseous lesion which occurs as an uncommon benign condition in jaws.
This case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection. An aggressive central giant cell granuloma in a pediatric. Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. We herein describe an intriguing case of a 21yearold male patient who was. Jun 19, 2018 this peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl. Central giant cell granuloma is a intraosseous benign lesion. Central giant cell granuloma cgcg is a benign intraosseous lesion of the jaws that is found predominantly in children and young adults. Four cases of central giant cell granuloma were treated with intralesional infiltration of a solution of kenacorta 10 mgml, triamcinolone aqueous suspension squibb and either 1 lidocaine 2%. For the previously reported cases in one female and three males, the mean age at presentation was 30 years. Zardawi2 bds, msc, phd 1department of oral and maxillofacial surgery school of dentistry, university of sulaimani, iraq. Multifocal central giant cell granuloma a case report. Central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology.
Primary hyperparathyroidism presented as central giant. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing case report open access radiotherapy for recurrent central giant cell granuloma. Recently, bisphosphonates have been used to treat central giant cell lesions. Imaging radiolucent destructive lesion with faint trabeculation and loculation. He presented with right side severe hearing loss and facial. Like pyogenic granuloma and peripheral ossifying fibroma, peripheral giant cell granuloma may represent an unusual response to tissue injury. Although central giant cell granulomas cgcgs appear to be benign, their radiographic findings are active. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Management of central giant cell granuloma of the jaws with. The condition was first identified in 1953 by jaffe, who initially termed this lesion as a central giant cell reparative granuloma, but nowadays the reparative word has been. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. The referring doctor had suggested a diagnosis of eruption cyst.
Surgery usually is the first choice in treatment of central giant cell granuloma. A central giant cell granuloma in posterior part of maxillaa case. Peripheral giant cell granuloma or the socalled giant cell epulis is the most common oral giant cell lesion. It is twice as common in females and is more likely to occur before age 30. Case report agressive central giant cell granuloma of the mandible. Multifocal central giant cell granuloma a case report article pdf available in iranian journal of pathology 1. Edwards p, et al re ported a case of central giant cell granuloma with bilateral mandibular involvement and associated with noonan syndrome. Benign condyle giant cell granuloma lesion mandible introduction maxilla, the epicenter is more commonly anterior to the giant cell granuloma was firstdescribed by jaffe 1953 condylar head, as opposed to lesions extending into the. Central giant cell lesions granuloma radiology reference. Pyogenic granuloma a case report open access journals. Pdf multifocal central giant cell granuloma a case report.
The aim of this article is to present a case of central giant cell granuloma mandible in a 22 year old female. It is an uncommon tumor in jaws, its etiology and pathogenesis is unknown. The central giant cell granuloma is a tumor that has great potential for the displacement of teeth and the development of a facial deformity. Discussion jaffe in 1953 first described giant cell reparative granuloma gcrg as a benign lesion that. Diffdx giant cell bone tumour, pthinduced brown tumour. This report presents a case of 22 year old female with central giant cell granuloma on right side of mandible. A case of a 36yearold male with a central giant cell lesion. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown etiology.
It occurs most commonly in mandible, but can also occur in maxilla. It may become aggressive leading to expansion and perforation of the cortex. Ct and mr imaging of giant cell granuloma of the craniofacial. Most reported cases involve isolated central giant cell granuloma or neurofibromatosis type 1nf1, and concurrence of these two entities is very rare.
These tumors become severely invasive with the stimulus of surgery, resembling malignant tumors. A report of three cases ibrahim saeed gataa1 bds, ficms faraedon m. Giant cell granuloma is often confused with giant cell tumour. Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs almost exclusively in the mandible, although cases in the skull and maxilla have been reported.
Cd68 expression in central giant cell granuloma report of 2 cases. The authors report a case of a large giant cell tumor involving the petrous and squamous portions of the temporal bone in a 26 year old male patient. Spontaneous resolution of a central giantcell granuloma. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg. An osteodestructive lesion of uncertain pathogenesis, which most commonly occurs in the young female mandible, and is more lytic than peripheral giant cell granuloma. This case report presents two cases of central giant cell granuloma, occurring in two females with an age of 14 and 45 years. Mar 21, 2012 central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. Koch, marcelo miranda, aline rc morosolli2 1 department of dental radiology faculty of dental medicine university of porto portugal. Central giant cell granuloma was first described by jaffe in 1953.
Peripheral giant cell granuloma associated with a dental. Histological evaluation of the possible transformation of peripheral giant cell granuloma and peripheral ossifying fibroma. There is a further population of bland, spindled, fibroblastslike cells with associated hemosiderin and scattered inflammation. Central giant cell granuloma of the maxilla bmj case reports. Central giant cell granuloma in a child case report. Central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive. Central giant cell granuloma is an uncommon benign proliferative lesion occurring more commonly in the anterior mandible. The article reports the case of central giant cell granuloma, affecting the anterior region maxillary of a child, whom a conservative treatment, with cryotherapy, helped the preservation of anterior permanent teeth germs. Jun 19, 2018 peripheral giant cell granuloma in anterior maxilla. The case reported here resembled a wide variety of conditions.
Extra oral examination revealed a diffuse swelling on the left side of. Kartagener syndrome with central giant cell granuloma. Thorough clinical and radiological examinations were performed. Spontaneous resolution of a central giantcell granuloma after incisional biopsy. The case described here involved maxilla which was treated with surgical excision. The central giant cell granuloma is a relatively common lesion of the jaws. Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the jaws though extragnathic incidence is rare.
Who defines this intraosseous lesions as a lesion that contains multiple foci of haemorrhage, consisting of cellular fibrous tissue and there is trabeculae of woven bone. Central giant cell granuloma cgcg is a benign intraosseous lesion first described by jaffe in 1953. Aug 22, 2012 central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. An aggressive central giant cell granuloma in a pediatric patient. This case is a rare occurrence of central giant cell. Case reports central giant cell lesion of mandible managed by intralesional triamcinolone injections. A 25 years old female patient was referred to the department of periodontics, yamunanagar with the chief complaint of a swelling in gums in relation to lower front region since 7 months. Giant cell tumor of the temporal bone a case report. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature, accounting for less than 7% of all benign jaw lesions. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio. Senior lecturer 1,2department of oral pathology and microbiology, kothiwal dental college and research centre, kanth road.
Case report a twenty two year old female patient reported to department of oral and maxillofacial surgery with chief complaint of painless swelling on right lower side of face since 1 year. Intralesional corticosteroid injection for central giant cell. It is distinguishable from pyogenic granuloma and peripheral ossifying fibroma only on the basis of its unique histomorphology, which is the same as central giant cell granuloma 8, 9. N11siry and umvhrsiiy oh thxas htaltil scibncli clntkr at san antonio the central giant cell granuloma is a tumor that has great potential for the displacement of teeth and the development of a facial deformity. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long bones. Central giant cell granulomas of the condyle are rare. A case report journal of indian society for pedodontics and preventive dentistry 2004. Between the giant cells are monocluate variants with similar nuclear profiles. Ten months later, the patient presented with a wellcircumscribed lesion associated with and covering the implant, at. Central giant cell granuloma of the mandible american. Oct 19, 2015 we report the results of the intralesional steroid injections for the management of central giant cell granuloma cgcg of the jaws. Thought to represent a reparative response to intrabony haemorrhage and inflammation, cgcg was once regarded as a reactive lesion. The petrous portion of the temporal bone forms a rare location for this tumor. The findings are consistent with central giant cell.
Central giant cell granuloma definition of central giant. Multiple synchronous central giant cell granulomas of the. We report a case of a large central giant cell granuloma of the condylar head with extension into the infratemporal fossa in a 29yearold male. Subramanyam classification of giant cell lesions 9. Cgcg lacks in clinical and radiographical pathognomonic features to distinguish from common lesions occurring in this region. It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the craniofacial bones. Central giant cell granuloma a case report ahmed s, babu i, priya. The giant cells contained only a few nuclei, up to dozen fig. Casereport munzenmayer j1, tapia p2, zeballos j2, martinez a3, compan a4, urra a5, spencer ml6 summary this case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection and reconstruction with fibula graft.
Primary hyperparathyroidism presented as central giant cell granuloma of jaw bones. Achieving the correct diagnosis is reportedly difficult because cgcgs are very similar to odontogenic jaw tumors. Central giant cell granuloma cgcg is a localised benign condition of the jaws. This case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection and reconstruction with fibula graft. A central giant cell granuloma in posterior part of. Central giant cell granuloma cgcg, multilocular, intralesional injections, corticosteroids.
This article describes a case of central giant cell granuloma in the right posterior region of the mandible in a 10 yearold boy. It occurs mostly in first three decades of life and commonly occurs in females. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature. Its etiology is unknown and its biological behavior is poorly understood. Giant cell granuloma, intralesional injection, microvascular free flap, fibula. Central giant cell granuloma report of a case brad,1. Central giant cell is a benign lesion that predominantly involves the bone of the mandible and maxilla with a wide varia. This article reports the case of a 25 years old female patient with pyogenic granuloma which was surgically managed.
Thus, the pathologic diagnosis was central giant cell granuloma. We present a case of an aggressive central giant cell granuloma cgcg in a six yearold female. Central giant cell granuloma is a benign lesion of the jaws which is sometimes aggressive locally. Intralesional corticosteroid injection for central giant cell granuloma. Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al. Central giant cell granuloma a case report balaji p, balaji s m. A central giant cell granuloma in posterior part of maxillaa.
The case report is of a 30 year old male, who complained of a slowly expanding swelling in the maxilla in the left premolar region. Combined treatment of aggressive central giant cell granuloma in the lower jaw. Central giant cell granuloma cgcg is an uncommon, benign, and proliferative lesion of the jaw with an unknown etiology. This case is a rare occurrence of central giant cell granuloma of the mandibular condyle. Aggressive central giant cell granuloma mimicking peripheral. This condition is a slowgrowing, asymptomatic lesion that usually affects children and young adults, predominantly females. Jul 20, 20 central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature. Central giant cell granuloma cgcg is an uncommon benign bony lesion that occurs in the mandible and maxilla. Agressive central giant cell granuloma of the mandible. We report a case of concurrent central giant cell granuloma with neurofibromatosis type 1.
It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible. It accounts for almost 7% of all benign lesions of the. Radiographically they appeared as welldefined unilocular or multilocular radiolucencies with undulating borders. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Incidence of central giant cell granuloma of the jaws with clinical and histological confirmation. Central giant cell granuloma cgcg of the jaws is a benign, intraosseous, osteolytic lesion of debatable etiology. Cgcl mandible and intralesional triamcinolone journal section.
The central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in toothbearing areas. Cd68 expression in central giant cell granuloma report. The true nature of this lesion is controversial and remains unknown. Peripheral giant cell granuloma or so called giant cell epulis is the most common oral giant cell lesion. The dental implant was originally placed in august 2012. Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. Central giant cell granuloma of the posterior maxilla.
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